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National Repository of Grey Literature 1 records found  Search took 0.01 seconds. 
The effect of opioids on the redox state of rat myocardium
 Jandová, Gabriela ; Novotný, Jiří (advisor) ; Roubalová, Lenka (referee)
The aim of this work was to study the expression of proteins involved in reactions in which harmful free radicals are degraded in an organism. was observed difference between the expression of selected myocardial proteins in non-influenced animals, animals who were treated with low dosage of morphine (0.1 mg/kg/day or 1 mg/kg/day), and animals administered high dosage of morphine (10 mg/kg/day). Low dosages were administered for 28 days and high dosage for 10 days. In addition, the effect of abstinence lasting one week was assessed after cessation of morphine administration (1 mg/kg/day). Morphine at low dosage (0.1 mg/kg/day) increased levels of glutathion peroxidase-1/2, which may be considered as one of the possible consequences of the ongoing oxidative stress. There were no significant differences in glutathion peroxidase-6 expression. Next aim of this work was to study the expression of antioxidant enzymes. These experiments were carried out on myocardial preparations from the animals treated with a constant dosage of morphine (10 mg/kg/day) for 10 days. Samples from these animals were used for measuring the total antioxidant capacity of the left and right ventricles. These samples were also used for determination of concentration of the oxidative stress marker 8-isoprostane. We also aimed to...
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